| President | Chief of Staff | Took office | Left office |
| Harry S Truman (Dem) | John Steelman | 1946 | 1953 |
| Dwight D. Eisenhower (Rep) | Sherman Adams | 1953 | 1958 |
| Dwight D. Eisenhower (Rep) | Wilton Persons | 1958 | 1961 |
| John F. Kennedy (Dem) | Kenneth O’Donnell | 1961 | 1963 |
| Lyndon B. Johnson (Dem) | Marvin Watson | 1965 | 1968 |
| Lyndon B. Johnson (Dem) | James R. Jones | 1968 | 1969 |
| Richard Nixon (Rep) | H. R. Haldeman | 1969 | 1973 |
| Richard Nixon (Rep) | Alexander Haig | 1973 | 1974 |
| Gerald Ford (Rep) | Alexander Haig | 1973 | 1974 |
| Gerald Ford (Rep) | Donald Rumsfeld | 1974 | 1975 |
| Gerald Ford (Rep) | Dick Cheney | 1975 | 1977 |
| Jimmy Carter (Dem) | Hamilton Jordan | 1979 | 1980 |
| Jimmy Carter (Dem) | Jack Watson | 1980 | 1981 |
| Ronald Reagan (Rep) | James Baker | 1981 | 1985 |
| Ronald Reagan (Rep) | Donald Regan | 1985 | 1987 |
| Ronald Reagan (Rep) | Howard Baker | 1987 | 1988 |
| Ronald Reagan (Rep) | Kenneth Duberstein | 1988 | 1989 |
| George H. W. Bush (Rep) | John Sununu | 1989 | 1991 |
| George H. W. Bush (Rep) | Samuel Skinner | 1991 | 1992 |
| George H. W. Bush (Rep) | James Baker | 1992 | 1993 |
| Bill Clinton (Dem) | Mack McLarty | 1993 | 1994 |
| Bill Clinton (Dem) | Leon Panetta | 1994 | 1997 |
| Bill Clinton (Dem) | Erskine Bowles | 1997 | 1998 |
| Bill Clinton (Dem) | John Podesta | 1998 | 2001 |
| George W. Bush (Rep) | Andrew Card | 2001 | 2006 |
| George W. Bush (Rep) | Joshua Bolten | 2006 | 2009 |
| Barack Obama (Dem) | Rahm Emanuel | 2009 | 2010 |
| Barack Obama (Dem) | Pete Rouse | 2010 | 2011 |
| Barack Obama (Dem) | Bill Daley | 2011 | 2012 |
| Barack Obama (Dem) | Jack Lew | 2012 | 2013 |
| Barack Obama (Dem) | Denis McDonough | 2013 | 2017 |
| Donald Trump (Rep) | Reince Priebus | 2017 | 2017 |
| Donald Trump (Rep) | John F. Kelly | 2017 | 2019 |
| Donald Trump (Rep) | Mick Mulvaney | 2019 | 2020 |
| Donald Trump (Rep) | Mark Meadows | 2020 | 2021 |
| Joe Biden (Dem) | Ron Klain | 2021 | Present |